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Drug Name Indication Neurotransmitter(s) Affected Target Symptoms Half-life (T1/2), Metabolism (CYP 450 enzyme) Notable Side Effects (link to NT

February 12, 2024

Drug Name	Indication Neurotransmitter(s) Affected Target Symptoms	Half-life (T1/2), Metabolism (CYP 450 enzyme)	Notable Side Effects (link to NT or affected brain circuit)	Initial Dosing Considerations Specific lifespan considerations (age, pregnancy, breastfeeding)
Buprenorphine (Subutex)
Buprenorphine/Naloxone (Suboxone, Zubsolv, Bunavail)
Methadone (Dolophine, Methadose)
Naltrexone (Revia, Vivitrol)
Acamprosate (Campral)
Disulfiram (Antabuse)

Instructions below:

1. For each medication listed, complete the following:

a. Provide indication, target symptoms, and affected neurotransmitters.

b. Include half-life and CYP 450 enzyme information.

c. List notable side effects and link notable side effects to the associated pathway or neurotransmitter.

d. List Initial Dosing Considerations and specific lifespan considerations (age, pregnancy, breastfeeding).

e. Organization font is consistent throughout table, grammar, spelling, and/or punctuation are accurate.

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